The #inkscape team called it "the unicode tofu issue" (https://gitlab.com/inkscape/inkscape/-/issues/3532), because "something something something, broken fonts" was making the UI unusable on macOS for some people. With the upcoming Inkscape 1.4.3 we can finally say: something something something, we win!
Spread the word, grab an artifact from https://gitlab.com/inkscape/inkscape/-/merge_requests/7627 and help us test!